KEGG pathway enrichment and siRNA-mediated knockdown experiments verified that WNT5A (Wnt family member 5A), APP (amyloid beta precursor protein), and APC (adenomatous polyposis coli WNT signaling regulator) are regulators that promote CAVD progression59. Here, WNT5A is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.