NOTCH1 and congenital bilateral aplasia of vas deferens from CFTR mutation: Machine learning strategies combined with targeted RNA-seq have been used to map gene networks disrupted in human NOTCH1 haploinsufficient iPSC-derived endothelial cells; XCT790 was screened to correct the impaired gene network signature and prevent CAVD initiation and progression in Notch1/mTRG2 mice25.