Screening of our library of CRBN-directed molecular glues against a panel of pediatric cancer cell lines led to the identification of SJ7095 with high cytotoxicity against MOLM-13 cells (IC50 = 71 nM), and potent CRBN-dependent degradation of CK1α, IKZF1 and IKZF3 proteins. The gene discussed is IKZF3; the disease is cancer.