While the potent and mixed CK1α and IKZF1/3 degradation profile displayed by SJ7095 has potential translational value, we were also interested in developing selective degraders that would be suitable for studying CK1α biology, as well as exploring potential therapeutic approaches for cancers where IKZF1/3 degradation is unnecessary or undesirable33–35. This evidence concerns the gene IKZF1 and cancer.