Long-term administration of the anti-inflammatory drug roflumilast to mice with secretory immunoglobulin A (SIgA) immunodeficiency due to polymeric immunoglobulin receptor (pIgR) deficiency prevents progressive tracheal wall remodeling and partial reversal of emphysematous alterations in SIgA-deficient mice. The gene discussed is PIGR; the disease is Immunodeficiency.