In summary, IRAK4 appears to be indispensable inTLR/IL-1R signaling,and activation of the IRAK4 pathway is associated with inflammatoryand autoimmune disorders such as atopic dermatitis, lupus erythematosus,hidradenitis suppurativa, and rheumatoid arthritis. The gene discussed is IRAK4; the disease is hidradenitis suppurativa.