In summary, IRAK4 appears to be indispensable inTLR/IL-1R signaling,and activation of the IRAK4 pathway is associated with inflammatoryand autoimmune disorders such as atopic dermatitis, lupus erythematosus,hidradenitis suppurativa, and rheumatoid arthritis. This evidence concerns the gene IRAK4 and lupus erythematosus.