C22orf46P and lung adenocarcinoma: Along these lines, we observed that C22orf46 knockout led to the significant depletion of genes (ES = −0.4, P < 0.01) previously shown to correlate with poor survival in NSCLCs (Fig 5B) (Director’s Challenge Consortium for the Molecular Classification of Lung Adenocarcinoma et al, 2008), implicating that C22orf46 might contribute to aggressiveness of lung carcinomas.