The gene C22orf46 encodes a nucleolar protein (Fig 3E), which diminishes T cell–mediated cytotoxicity in NSCLC cells (Fig 2) and has been reported to be significantly up-regulated in a broad range of various cancer entities including lung carcinomas (P = 2.5 × 10−30) (Bartha & Gyorffy, 2021) (Fig 4B). Here, C22orf46P is linked to cancer.