MMP9 and ventricular septal defect 1: STIGMA successfully predicted several gene-disease associations, such as UBA2 (MIM: 613295), which was recently reported to be related to limb malformations,31 as well as ALDOB (MIM: 612724) and MMP9 (MIM: 120361) that have been associated with ventricular septal defect (MIM: 614429).32