Interestingly, PHIP and UBA2, which have been associated with similar disease profiles of oligodactyly and ectrodactyly, respectively, also showed similar temporal expression patterns in mesenchymal-chondrocytes, -fibroblasts, ectodermal-sost, and muscle cells (Figures S5B, S5D, S5E, and S5G). Here, UBA2 is linked to split hand-foot malformation.