Liu et al reported that Alkbh5 deficient mice were resistant to infection by a range of DNA and RNA viruses (VSV, HSV-1 EMCV) mediated by an m6A RNA-dependent down regulation of the α-ketoglutarate dehydrogenase (OGDH)-itaconate pathway that promoted virus replication [65]. The gene discussed is ALKBH5; the disease is infection.