It also provides a rationale that supports the clinical development of APOL1 modulators such as inaxaplin (ClinicalTrials.gov NCT04340362) and inhibitors of APOL1 synthesis such as Janus kinase-STAT inhibitors (ClinicalTrials.gov NCT05237388) as promising therapeutic strategies for APOL1-mediated kidney disease. The gene discussed is APOL1; the disease is kidney disorder.