SPARC and infection: Other hypercapnia-regulated genes map to processes downregulated by elevated CO2 that could also influence outcomes of infection; these include cell migration (Csf1, Cyr61, Hbegf, Mmp14, Pdgfr), wound healing (Dcbld2, Hpse, Mmp12, Mustn1, Pdgfb, Pdgfra, Slc11a1, Sparc, Timp1), collagen biosynthesis (Arg1, Col1a1, Col3a1, Serpinh1), and chitin catabolism (Chil3 and Chil4).