ADIPOQ and obesity due to melanocortin 4 receptor deficiency: On the other hand, we found that the MRD for BMI was stronger among men, consistent with a previous meta-analysis.6 Similar findings also exist in risks of cardiovascular disease,39,40,41 diabetes,42 and some cancers.43 These findings might be explained by the fact that, compared with their female counterparts, men with obesity have more abdominal and visceral fat accumulation,44 lower concentration of antiatherogenic and anti-inflammatory adiponectin,45,46,47,48 and higher cancer risks associated with higher concentrations of free insulin–like growth factor 1.49,50