LRRK2 and Parkinson disease: Interestingly, both LRRK2 and ATG16L1 are identified as risk genes for inflammatory diseases, including systemic lupus erythematosus (Zhang et al., 2017; Zhou et al., 2011) and Crohn’s disease (Barrett et al., 2008; Hampe et al., 2007; Rioux et al., 2007), suggesting that LRRK2 and the ATG8 conjugation system components could act in a common pathway contributing to the pathogenesis of immune-related diseases in addition to PD.