The relationship between LRRK2 and macroautophagy has been repeatedly reported in studies of PD mechanisms (Madureira et al., 2020; Manzoni and Lewis, 2017), and a couple of studies showed the increase in the amount of lipidated LC3 (or ATG8 orthologues) in actual PD brains (Dehay et al., 2010; Tanji et al., 2011). Here, LRRK2 is linked to Parkinson disease.