ESR1 and breast carcinoma: Recently, we reported in vitro antiproliferative and cytotoxic activities of a novel triorganotin compound, triphenyltin isoselenocyanate (TPT-NCSe) (Fig. 1), in human breast carcinoma MCF-7 (estrogen receptor positive) and MDA-MB-231 (triple negative) cell lines, the synthesis and analysis of which have been described precisely in our previous article [12].