As for CD14, already exhibited in harvested IVD-derived mononuclear cells from patients with lumbar disc herniation (Stevens et al. 2000), it stands as a macrophage marker responsible for expressing some of the inflammatory cytokines, calcitonin gene‐related peptide (CGRP) (Miyagi et al. 2020) and nerve growth factor (NGF) (Miyagi et al. 2020; Nakawaki et al. 2019), through paracrine or autocrine systems, leading ultimately to discogenic LBP. The gene discussed is NGF; the disease is lumbar disc herniation.