SPRY4 and urinary bladder cancer: As depicted in Table 1, exosomal lnc-MALAT1, PCAT-1, and SPRY4-IT1 from urine [6]; exosomal lnc-UCA1-201, UCA1-203, MALAT1, and LINC00355 from urine [8]; exosomal lnc-PCAT-1, UBC1, and SNHG16 from serum [10]; exosomal lnc-MIR205HG and GAS5 from urine [12]; exosomal miR-96-5p and miR-183-5p from urine [15]; exosomal miR-93-5p and miR-516a-5p from urine [16]; and exosomal lnc-RMRP, UCA1, and MALAT1 from urine [18] all manifested satisfying diagnostic value for bladder cancer.