There has been limited morphological research regarding the comparison of these genes within orofacial cleft tissue; ergo, taking into account the significance of these genes in craniofacial development, the objectives of this study were to examine the presence, distribution, and potential correlation between PAX7, PAX9, SHH, SOX3, WNT3A, and WNT9B in postnatal CLP-affected cleft palatine tissue. The gene discussed is SOX3; the disease is orofacial cleft.