P-gp is a human ABC-transporter of the MDR/TAP subfamily that transports various substrates out of cells including taxanes, BRAF inhibitors (vemurafenib, dabrafenib, encorafenib) and MEK inhibitors (trametinib, cobimetinib, binimetinib) and numerous other cancer therapies [8–11]. The gene discussed is PGP; the disease is cancer.