LRP6 has been reported to have a role in promoting epithelial cell tumors such as hepatocellular carcinoma, colorectal carcinoma, and pancreatic ductal carcinoma, which correlates with tumor malignant phenotype, metastatic potential, and poor prognosis, and is accompanied by increased wnt/β-catenin signaling [13–17]. The gene discussed is LRP6; the disease is neoplasm.