It can be triggered in cancer cells by depletion of glutathione (GSH) and the amino acid cysteine or by inhibition of glutathione peroxidase 4 (GPX4) [34], but it can be blocked by the iron chelator desferrioxamine (DFO) and by inhibitors of lipid peroxidation, such as ferrostatin-1, liproxstatin-11, etc. Ferroptosis is an intracellular iron-dependent form of cell death, distinct from apoptosis, necrosis, and cellular autophagy [28]. Here, GPX4 is linked to cancer.