LRP6 and clear cell renal carcinoma: Here, we found that LRP6 is abnormally highly expressed and significantly correlated with microsatellite instability (MSI), tumor mutation burden (TMB), and immune cell infiltration and immune checkpoint expression in a variety of tumors, including renal, breast, colorectal, and lung cancers, etc. Moreover, we found that LRP6 was significantly associated with the prognosis of renal clear cell carcinoma.