LRP6 and glioblastoma: Using data from the TCGA database we investigated the relationship between LRP6 and tumor TMB and MSI, and found that LRP6 expression was significantly positively correlated with tumor TMB in LUSC, TGCT, GBM, READ, and KICH, and significantly negatively correlated with tumor TMB in DLBC, UCS, etc., (Figure 2A).