IGFBP1 and clear cell renal carcinoma: To investigate whether LRP6 may affect renal clear cell carcinoma progression by regulating m6A, we analyzed the correlation between LRP6 and the expression of m6A-related genes, including class “writter” genes (METTL3, METTL14, ZC3H13, VIRMA, WTAP, RBM15 and RBM15B), class “eraser” genes (FTO and ALKBH5), and class “reader” genes (YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, HNRNPC, HNRNPA2B1, IGFBP1, IGFBP2, IGFBP3 and RBMX), and found that there was a significant correlation between LRP6 and all 20 m6A-related genes (Figure 6).