CD8A and Sepsis: Measurement of CTLA-4 expression in the CD4+Foxp3− Tconv (CD4+ Tconv), CD4+Foxp3+ Treg (CD4+ Treg), and CD8+ T cell compartments of these mice after alcohol exposure and tamoxifen administration followed by CLP verified decreased CTLA-4 expression on both CD4+ Tconv and CD4+ Treg during sepsis (Fig. 2A).