UBE2L3 and neoplasm: To determine whether Cul1 and Ube2l3 overexpression suppresses HPV+ HNC tumor growth, we generated mEERL cells overexpressing Cul1 (mEERL/Cul1) or Ube2l3 (mEERL/Ube2l3) using lentiviruses and blasticidin selection.