Our findings indicate that ELANE rs17223045C/T (C vs T: odds ratio [OR] 0.08, P ═ 0.005, and CC vs CT: OR 0.08, P ═ 0.005) and rs3761007G/A (G vs A: OR 0.38, P ═ 0.009, and GG vs GA: OR 0.40, P ═ 0.008) confer protection against COVID-19. This evidence concerns the gene ELANE and COVID-19.