25 Additionally, a previous study demonstrated the neuroprotective effect of Maf1 on survival after root ganglion cell injury and provided a potential treatment strategy for traumatic optic neuropathy.26 As a result, Maf1 has become a hot topic, and it is therefore now possible to further clarify the mechanism of synaptic remodelling by exploring the morphology and potential function of Maf1 in regulating neuronal synapses. The gene discussed is MAF1; the disease is optic nerve disorder.