Maf1 is a eukaryote-specific gene in humans, rats, mice and lower animals such as Drosophila and silkworm, and it encodes a highly conserved protein.8 Maf1, first discovered in Saccharomyces cerevisiae, can be a transcriptional regulator of RNA polymerase III and plays an essential role in tumour suppression, glucose metabolism, lipid metabolism and other events by activating the PTEN pathway.9 In recent years, Maf1 has been found to bind and block RNA polymerase III-regulated transcription initiation and elongation. The gene discussed is MAF1; the disease is neoplasm.