Various factors have been shown to increase the risk of CIP, including use of PD-1/PD-L1 agents (52, 53) (compared with CTLA-4 inhibitors), combination immunotherapy (54, 55) (CTLA-4 and PD-1 combination rather than monotherapy), radiotherapy (56, 57), and the organ of tumor origin (58, 59) (e.g., NSCLC vs. renal cell or other cancer types). This evidence concerns the gene CD274 and hereditary sensory and autonomic neuropathy.