CSF3 and pneumonitis: For example, in a discovery cohort of 58 patients with melanoma, samples taken at baseline and at the time of toxicity identified 11 signature cytokines (including granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor, fractalkine, basic fibroblast growth factor-2, IFN-α2, IL-12p70, IL-1a, IL-1β, IL-1 receptor agonist, IL-2, and IL-13) that strongly correlated with the development of severe irAEs, including two cases of pneumonitis (100).