Another study looking specifically at 204 patients with NSCLC, of which 43 developed irAEs, found a similar proinflammatory increase in IL-1β cytokine but also elevations in IL-5, IL-8, IL-10, IL-12p70, and granzyme A and decreased G-CSF as predictors for irAEs that included pneumonitis (5 of a total of 43) (101). The gene discussed is IL5; the disease is pneumonitis.