Interestingly, we also found that STX4 is associated with several pathways that play significant roles in ccRCC progression, including the VEGF signaling pathway, mTOR signaling pathway, NF−κB signaling pathway, MAPK signaling pathway, and HIF−1 signaling pathway (Fig. 2C). Here, NFKB1 is linked to nonpapillary renal cell carcinoma.