LncRNA plasmacytoma variant translocation 1 (PVT1) is associated with the development and progression of cancers. Functional studies on HCC cell line SMMC-7721 demonstrated that lncRNA PVT1 may promote liver cancer progression by inhibiting histone methylation on the MYC promoter, signifying it as potential target for therapeutic strategies of the malignancy. The gene discussed is PVT1; the disease is hepatocellular carcinoma.