The Hippo signaling pathway has been confirmed to involve in HCC development and progression through regulating key Hippo-related genes, including Sav1, Mst1/2, Mob1a/b and Lats1/2. Moreover, the Hippo regulation role of lncRNAs has been reported in HCC tumorigenesis mainly by affecting YAP/TAZ [27]. Here, SAV1 is linked to hepatocellular carcinoma.