When Dsg3H1-pTh17 cells were transferred into irradiated syngeneic wild-type C57BL/6 mice, they induced dermatitis at a slower rate than in Cd3e KO recipients (which lack endogenous T cells and showed EAD with kinetics similar to Rag2 KO recipients) (Figure 1B). This evidence concerns the gene CD3E and dermatitis.