The tumour suppressor markers early growth response 1 (EGR1) (Fig. 7E) and dual specificity phosphatase 6 (DUSP6) (Fig. 7F) [32] were downregulated by ∼2-fold in the presence of a bone stroma compared to a fibroblast stroma (p < 0.005). The gene discussed is EGR1; the disease is neoplasm.