Recent studies have elucidated the role of SENP1 in cardiac hypertrophy.[26] The expression of SENP1 is dysregulated in hypertrophic hearts, exerting a profound effect on cardiac remodeling.[27] To determine whether the expression of SENP1 is associated with cardiac hypertrophy, we measured the mRNA and protein expression levels of SENP1 in a TAC surgery‐induced hypertrophic mouse model and in NRCMs treated with Ang II. This evidence concerns the gene SENP1 and cardiac hypertrophy.