Mutations in the RNF43 gene are observed in neoplastic cysts of the pancreas, indicating that it is an early event in pancreatic tumorigenesis and is crucial for tumor formation.[12] As the K‐RAS mutation also occurs in the pre‐cancerous lesions of pancreas, we hypothesized that RNF43 inactivation may help the cells escape from K‐RAS‐induced senescence. The gene discussed is KRAS; the disease is neoplasm.