In addition, analysis of pancreatic adenocarcinoma patients in The Cancer Genome Atlas (TCGA) database showed similar B‐RAF mRNA levels among the patients, but dramatically high B‐RAF protein levels in patients with mutated RNF43 (Figure 6F), supporting our hypothesis that RNF43 controls B‐RAF abundance via post‐translational regulation. Here, RNF43 is linked to pancreatic adenocarcinoma.