Three clinically identified small deletions (ΔNVTAP, ΔTAPTP, and ΔPTPQQ) close to or containing T491 in B‐RAF, reported in pancreatic and thyroid cancers, also alter the structure and activation of B‐RAF.[27] Dynamic phosphorylation of T491 may be a critical mechanism for controlling the stability of B‐RAF under various physiological and pathological conditions. The gene discussed is BRAF; the disease is thyroid cancer.