Although no interaction between PAK5 and RNF43 was detected, RNF43KO PANC‐1 cells with depleted B‐RAF or PAK5 showed considerably reduced colony‐forming abilities (Figure S2B, Supporting Information) compared to PANC‐1 cells, indicating that RNF43 may regulate the proliferation of pancreatic cancer cells via B‐RAF or PAK5. Here, BRAF is linked to familial pancreatic carcinoma.