FZD5 and cancer: Using a genome‐wide clustered regularly interspaced palindromic repeat (CRISPR) approach, a previous study demonstrated that the WNT receptor FZD5 signaling circuit is vulnerable in RNF43‐mutated pancreatic cancer.[10] To identify the altered signaling pathways and druggable targets in RNF43‐mutated cancer cells, we performed kinase inhibitor library screening in RNF43‐mutated pancreatic cancer cells (AsPC‐1 and HPAF‐II) and RNF43‐wild‐type PANC‐1 cells.