BRAF and malignant colon neoplasm: B‐RAF is a key upstream activator of mitogen‐activated protein kinase kinase (MEK) and extracellular signal‐regulated kinase (ERK) signaling that stimulates cell proliferation.[6] Gain of function mutations in the B‐Raf gene are frequently observed in melanoma, colon cancer, and lung cancer.[7] Numerous studies suggest that B‐RAF is a critical driver of oncogenesis.[8] In addition, the location of mutations in the B‐RAF protein substantial affects RAS dependency, dimerization, and drug response.[9]