TBK1 and cancer: Subsequently, a signaling cascade leads to the production of type I interferons (IFNs) and pro‐inflammatory cytokines against pathogens and cancer cells.[4] However, mutp53 can inhibit the cGAS‐STING pathway by interacting with TANK‐binding kinase 1 (TBK1) and preventing the formation of trimeric complex between TBK1, STING, and IRF3, which is required for the activation of IRF3.