The human MUC16 epitope targeted by the vaccines herein (GYSPNRNEPLTGNSDLPFWA) includes these key membrane proximal twelve amino acids based on the hypothesis that the vaccination-induced antibody should not target the bulk of MUC16 that is shed, but rather this stub that remains on the tumor cell surface after release of CA125 [16]. Here, MUC16 is linked to neoplasm.