The latter was also over-expressed in monocytes, where the S protein behaved similarly to a series of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) massively released in COVID-19 that induce TF expression in leukocytes and non-immune cells, favoring a hypercoagulable state and thrombus formation [56]. The gene discussed is IL6; the disease is COVID-19.