In addition to smaller body sizes, as reported before [19], live-born Armc5 KO mice in the CD1 x C57BL/6 F1 background presented significantly high incidences of kinky tails, a form of NTD [47, 48], upon visual inspection (Fig. 1D) or micro-CT imaging (Fig. 1E). Here, ARMC5 is linked to neural tube defect.