As a critical cofactor, Mg could be helpful to exert biological functions in any reaction powered by adenosine triphosphate (ATP); as a phosphate binder, Mg could be helpful to decrease hyperphosphatemia and vascular calcification [40, 41]; as a calcium channel antagonist, Mg could involve in regulating various activity accompanied by intracellular calcium concentration fluxes, such as contraction of muscles, release of insulin [42]. This evidence concerns the gene INS and hyperphosphatemia.