Some studies suggest that greater involvement in women may be related to a different expression of angiotensin converting enzyme 2 (ACE-2) or transmembrane protease serine 2 (TMPRSS2) receptors or to lower production of proinflammatory cytokines such as interleukin-6 (IL-6) in women after a viral infection [49]. The gene discussed is ACE2; the disease is viral infectious disease.