Additionally, the androgen-dependent LNCaP cell line was also transfected with overexpression plasmid, and transwell assays showed that circCCDC7(15,16,17,18,19) could suppress the migration and invasion of LNCaP, suggesting that the mechanism of inhibiting PCa is not dependent on AR status (Supplementary Fig. 5d, e). The gene discussed is AR; the disease is posterior cortical atrophy.