TRIM3 and neoplasm: Brat in Drosophila brains, and TRIM3 in GBM cells, supress MYC expression, and MYC inhibition reduces both brat tumour growth and GSC tumourigenic potential in vitro and when xenotransplanted in mice (Betschinger et al, 2006; Chen et al, 2014; Wang et al, 2008).