Endoribonuclease-prepared small interfering RNAs (esiRNA) and lentivirus-delivered short hairpin RNA (shRNA) against HEATR1 knock it down efficiently in GBM (U87MG, U251MG) and GSCs (GSC-5 and GSC-8) derived from independent tumours (Appendix Fig. S2A,B). Here, HEATR1 is linked to glioblastoma.