MYC and Burkitt lymphoma: HEATR1 contains a canonical Myc-binding E-box (CACGTG) in its promoter and has been proposed as a MYC transcriptional target in a genome-wide analysis of MYC-binding sites in Burkitt lymphoma cell lines by chromatin immunoprecipitation followed by sequencing (ChIP-Seq) (Seitz et al, 2011) and in Drosophila S2 cells (Furrer et al, 2010; Hulf et al, 2005), with these studies also reporting that MYC inhibition decreases HEATR1 expression.