In support, HEATR1 expression in glioma negatively correlates with patient survival but a positive correlation was also found in pancreatic ductal adenocarcinoma where it is thought to aid sensitization to chemotherapeutic gemcitabine via AKT signalling inactivation (Fang et al, 2020; Liu et al, 2016). The gene discussed is AKT1; the disease is central nervous system cancer.