Brat and TRIM3 can attenuate Notch signalling at least in part via supressing nuclear transport of Notch intracellular domain (NICD) in a process dependent on the Importin complex (Mukherjee et al, 2016); in addition, both inhibit the expression of the oncogene MYC in Drosophila brains and GBM tumourspheres, respectively (Betschinger et al, 2006; Chen et al, 2014; Song and Lu, 2011; Zaytseva et al, 2020). This evidence concerns the gene MYC and glioblastoma.