We next analysed HEATR1 inhibition at 48 h ALH, a developmental stage when brat TICs started to overproliferate to form a tumour and will grow indefinitely as demonstrated via serially transplant paradigms (Bowman et al, 2008; Caussinus and Gonzalez, 2005; Landskron et al, 2018). Here, HEATR1 is linked to neoplasm.