TARDBP and amyotrophic lateral sclerosis: In particular, the functions regarding protein polymerization and folding have been postulated: importin α/β inhibits the fibrillization of TDP-43, which is associated with amyotrophic lateral sclerosis and Alzheimer’s disease60,61, and in influenza A virus, importin α5 acts as a chaperone that inhibits the aggregation of nucleoprotein62.