Bayesian network depicted clinically relevant IPF-specific networks, which are mainly consisted of 6 modules including TGF-β-related module (major components: TGF-β and LRC32 proteins), fibrosis-related module (A2MG and PZP proteins), complement-related module (C1QC and SAA2 proteins; neutrophil, eosinophil and lymphocyte counts), module related to inflammation and myofibroblast proliferation (LRP1 and ITIH4 proteins), module related to serological markers and clinical findings (PSPB protein; serological markers, KL-6 and SP-D; and fine crackles), and tubulin-related module (TBB1 and TBB5). The gene discussed is SFTPB; the disease is idiopathic interstitial pneumonia.