Submodule 1 consisted of 312 proteins, including 17 of the top HF-associated proteins identified in the single-protein analysis, and was enriched for several canonical pathways including Ephrin receptor signaling, STAT3 pathway, atherosclerosis signaling, and PI3K/AKT signaling relevant to cardiac hypertrophy and remodeling, among others (Supplementary Data 10). The gene discussed is AKT1; the disease is atherosclerosis.