Interestingly, the ZBTB7B gene signature (Fig. S9 and Table S9) significantly overlaps with the signatures of hepatoblastoma (ref. [41]) (42 of 140 in ZBTB7B gene signature, FDR q value 4.69E-26), liver-specific genes (ref. [16]) (23 of 140 in ZBTB7B gene signature, FDR q-value 1.32E-22), HCC subclass characterized by increased proliferation, high AFP levels and chromosomal instability (ref. [42]) (18 of 140 in ZBTB7B gene signature, FDR q value 5.61E-18), and HCC subtype associated with hepatocyte differentiation (ref. [37]) (18 of 140 in ZBTB7B gene signature, FDR q value 3.30E-15). This evidence concerns the gene AFP and hepatocellular carcinoma.