PPI sub-network of DEGs and DEPs synergistically regulated by ZBTB7B and Akt/N-Ras oncogens (clusters 2, 4, 5, and 6) further revealed c-Jun as the central signaling node in accelerated liver cancer initiation in the Zbtb7bΔli livers (Fig. 4D). The gene discussed is JUN; the disease is liver cancer.