AKT1 and hepatocellular carcinoma: Ras/MAPK and PI-3 kinase/Akt signaling were substantially more activated in the Zbtb7b-deficient livers upon Akt/N-Ras oncogene expression (Fig. S5B), suggesting that ZBTB7B may regulate HCC initiation at least partly by regulating MAPK and Akt function in a c-Jun-dependent manner.