ZBTB7B and hepatocellular carcinoma: Association and linear regression analyses demonstrated a tight correlation between ZBTB7B signature and liver-specific gene expression levels in human HCC (Fig. 8E), consistent with the finding that ZBTB7B was an adult liver-enriched transcription factor (Fig. S1) and expression of adult liver-specific genes were significantly downregulated in the Zbtb7bΔli livers (Fig. S1B).