INS and Hypoglycemia: Although ultimately hypoglycemia is caused by the mismatch between glucose levels andinsulin availability, the PK data show that both icodec and efsitora have flatter insulinexposure profiles compared to once-daily basal insulins, which may translate to aday-to-day hypoglycemia risk that could be similar to or perhaps even potentially lowerthan once-daily basal insulins.