Health care providers highlight multiple challenges with insulin titration(treatment inertia) with again concerns about side effects, especially hypoglycemia andweight gain, as well as a lack of resources to train patients, and concerns aboutpatients’ potential for nonadherence (133,136-138).Patients themselves also cite hypoglycemia and weight gain as concerns along with theperception that being on insulin means having a more severe disease. The gene discussed is INS; the disease is Hypoglycemia.