INS and Hypoglycemia: In addition, since the once-weekly insulin would takelonger to dissipate compared to once-daily insulins, one could argue that if frequentlevel 1 hypoglycemia occurs (which is considered an alert level) this could be a triggerto widen the glucose targets and/or initiate a proactive reduction in the dose of theonce-weekly insulin, bearing in mind that the effect of the reduced dose might notmanifest immediately.