INS and Hypoglycemia: Although these hypoglycemia data in insulin-naive people with T2D are reassuring with alow frequency of events, particularly given that all 3 studies showed statisticalsuperiority with regard to HbA1c reduction, icodec-treated patients generallyhad higher event rates of hypoglycemia, especially when compared to IDeg, and cautionwould be appropriate in the less meticulously monitored real-world use until health careproviders and patients accrue more experience with this therapy.