However, the short duration ofaction of IDet, ie, t1/2 = 5-7 hours, and clearance of 8.4 L/h, which is onlyapproximately 10 times slower than endogenous insulin, necessitated twice-daily dosingin many patients to provide adequate daily basal insulin coverage, especially in thosewith T1D (1, 19, 58). This evidence concerns the gene INS and type 1 diabetes mellitus.