Since the results of the study showed that the one-time starting-dosestrategy was the most effective in increasing TIR and avoiding transient hyperglycemia,a loading-dose strategy, albeit with a lower loading dose of an additional 50% insteadof 100%, was employed in the phase 3 icodec program for patients switching from aonce-daily to a once-weekly basal insulin (88). Here, INS is linked to Hyperglycemia.