The chromosome 11 peak (rs12362545, p-value=1.24e–06) is located in the PPFIA binding protein 2 (PPFIBP2) gene (Figure 1—figure supplement 4), which plays a role in axon guidance and neuronal synapse development and has previously been implicated in cancer development (Colas et al., 2011; Wu et al., 2018). Here, PPFIBP2 is linked to cancer.