EPHA4 and amyotrophic lateral sclerosis: Subsequent work in mouse models (Ling et al., 2018; Rué et al., 2019b; Zhao et al., 2018) showed that genetic reduction of EphA4 in SOD1G93A mice or intracerebroventricular delivery of an antisense oligonucleotide directed against EphA4 in both SOD1G93A and PFN1G118V mouse models of ALS did not impact disease measures.