In our previous work, we instead used the Gfa2 promotor to direct highly astrocyte-specific transduction in the adult rodent spinal cord (Li et al., 2015b; Falnikar et al., 2016; Li et al., 2015a; Li et al., 2014), which is an example of an approach moving forward to achieve astrocyte ephrinB2 knockdown in ALS animal models. Here, EFNB2 is linked to amyotrophic lateral sclerosis.