EPHA4 and amyotrophic lateral sclerosis: Expression of EphA4 in MNs significantly contributes to MN degeneration and overall disease pathogenesis in both rodent and zebrafish animal models of ALS (Van Hoecke et al., 2012), while reduction of ephrinA5 worsens disease outcome in an ALS mouse model (Rué et al., 2019a).