Other than in a relatively small number of studies (Van Hoecke et al., 2012; Rué et al., 2019a; Ling et al., 2018; Rué et al., 2019b; Zhao et al., 2018; Tsuda et al., 2008; Tyzack et al., 2017; Zhao et al., 2017), the role of Eph-ephrin signaling in ALS has not been extensively examined. Here, EPHA1 is linked to amyotrophic lateral sclerosis.