In the present study, we found that acetylation at K226, but not at K142, is impaired in mouse Huntington's disease (HD) derived striatal neuronal cells (Q111), which is consistent with previous reports and our present study showing selective degradation of CBP in HD mouse-derived striatal neuronal cells (Q111) compared to WT (Q7) cells. Here, CREBBP is linked to Huntington disease.