PNPLA3 and metabolic dysfunction-associated steatotic liver disease: Notably, the patatin‐like phospholipase domain containing 3 (PNPLA3) p.I148M variant is the main genetic modifier of MASLD susceptibility, but the molecular mechanisms underpinning the liver phenotype expression are still debated, although it seems to require an accumulation of the mutant protein on lipid droplets in hepatocytes.2