This syndrome is caused by complete loss of the ANP‐converting enzyme Corin due to a homozygous loss‐of‐function variant in the CORIN gene (NM_006587.4: c.684dupG; p.Met229Aspfs*16)4; CORIN has been previously implicated in preeclampsia (OMIM *605236). This evidence concerns the gene CORIN and preeclampsia.