SLC26A3 and colorectal cancer: As Caco2BBe cells can self-differentiate into an epithelial monolayer with features resembling native colonic epithelium (while also retaining aspects of malignant cells), these SLC26A3 knockout cells may prove a useful and informative addition to the armamentarium of reagents with which to better understand the regulation of ion transport functions in colonic enterocytes and colorectal cancer cells.