POMC and hypertensive disorder: Ouabain-resistant mutation of α2 NKA (α2R/R) or knockout of cardiovascular α2 NKA (CV-α2S/S-KO) in mice prevents or greatly attenuates hypertension; if, in the a2R/R mice, α1 is made ouabain-sensitive (i.e., α1S/Sα2R/R, or SWAP, mice), ACTH raises BP