Also, knockout, by ∼90%, of the α2 NKA isoform in mouse cardiac muscle [C-α2S/S-KO; (116)] or both cardiac and VSM [CV-α2S/S-KO (410)] has little effect on basal BP, whereas CV-α2S/S-KO, but not C-α2S/S-KO, prevents ACTH-induced hypertension (Fig. 9, D and E and Table 5) (410). The gene discussed is POMC; the disease is hypertensive disorder.