CMTM7 and cancer: CMTM7 is widely expressed in various tissues but is downregulated or not expressed in some malignant tumors, such as pancreatic and esophageal cancer, suggesting that CMTM7 may participate in tumor development and metastasis, play a tumor suppressive role, and behave as an inhibitory site for many tumors (Chen et al., 2023; Xie, Cheng & Zhang, 2023).