In a bioinformatics study that conducted gene set variation analysis of transcriptome data from 1,862 glioma samples available from CGGA RNA sequencing, TCGA RNA sequencing, CGGA microarrays, GSE16011 data, and IVY GBM databases, CMTM6 expression was positively correlated with immunosuppressive factors such as induced T-cell tolerance, cytokine synthesis and secretion, and regulatory T-cell differentiation (Guan et al., 2018b). Here, CMTM6 is linked to central nervous system cancer.