To investigate this potentially new regulator of PD-L1 expression, Burr et al. (2017) performed a whole-genome CRISPR–Cas9 deletion library screen using the pancreatic cancer cell line BxPC-3 and observed that IFN-γ can indeed stimulate the expression of endogenous PD-L1. Here, CD274 is linked to familial pancreatic carcinoma.