STAT3 and gastric cancer: CMTM3 expression is silenced or downregulated in gastric cell lines and primary tumors; it could inhibit EMT by upregulating E-calcineurin expression and downregulating N-calcineurin, waveform protein, and Twist1 expression, suggesting that CMTM3 inhibits gastric cancer metastasis by regulating the STAT3/Twist1/EMT signaling pathway (Huang et al., 2019; Yuan et al., 2016).