CD8A and neoplasm: This observation suggested that peritumoural CD4+ TILs, rather than CD8+ TILs, had an important impact on the recurrence of CRC, in consistent with the commonly held belief that an abundance of TILs contact with tumor cells, but they often fail to control disease, partly due to the increased ratio of suppressive immune cells, such as CD4+Treg (Hariyanto, Permata & Gondhowiardjo, 2022).